Angelina Jolie took the supporting role of the sociopathic Lisa Rowe in Girl, Interrupted (1999), a film that tells the story of mental patient Susanna Kaysen, and which was adapted from Kaysen's original memoir Girl, Interrupted. While Winona Ryder played the main character in what was hoped to be a comeback for Jolie, the film instead marked her final breakthrough in Hollywood. Angelina Jolie won her 3rd Golden Globe, her 2nd Screen Actors Guild Award and an Academy Award for Best Supporting Actress. Variety noted, "Jolie is excellent as the flamboyant, irresponsible girl who turns out to be far more instrumental than the doctors in Susanna's rehabilitation".
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